Orthostatic Hypotension And Its Relationship To The Brain Circulation Of Patients With Parkinson’s Disease: A Transcranial Doppler Assessment (P6.043)

• DOI: 10.1212/wnl.84.14_supplement.p6.043
• Publication Date: 2023-12-06T23:42:28Z
• Authors: Carlos Camargo; Eduardo Martins; Henrique Hoffmann; Jissa Jeanette; Marcelo Young-Blood; Marcelo Schafranski; Marcelo Ferro; Edmar Myochi; Marcos Lange
• Keywords: Transcranial Doppler; Cerebral circulation

Objective: The aim was to identify changes in cerebrovascular autoregulation patients with orthostatic hypotension (OH) associated Parkinson9s disease (PD). Background: PD is characterized by degeneration of specific neurons slow caudal-rostral progression. This the main explanation for non-motor manifestations disease. Usually, decrease systemic blood pressure offset an increase sympathetic tone and dilation cerebral vessels. Changes mechanisms maintain flow possibly occur onset OH. transcranial Doppler (TDC) a method monitor this dynamic. Methods: An analytical observational case-control type, which 22 subjects, divided into three groups were selected: OH, without OH controls. TCD evaluated initial average speed (Si), apnea (Sa), increased rate (R) breath holding index (BHI). Results: Patients have lower Si (46.41 ± 11.38 vs 54.42 12.03, p = 0.019, Cohen9s d 0.65), Sa (58.88 12.9 75.15 20.07, 0.0015, 0.964) BHI (9/21 3/22, 0.04, OR 4.75 95[percnt] CI 1.07 21.14) than had (61.27 12.26 0.02; 0.835), R (37.94 20.53 24.65 14, 08, 0.032, 0.755) (0.96 0.75 1.35 0.74, 0.52) PD-OH normal older (70.67 7.09 55.67 11.33, 0.01; -1.59) those standard BHI. Conclusion: exhibit self-regulatory circulation, could be indicative compensatory mechanisms. Disclosure: Dr. Camargo has nothing disclose. Martins Hoffmann Jeanette Young-Blood Schafranski Ferro Myochi Lange