Liposome-Encapsulated Ropivacaine for Topical Anesthesia of Human Oral Mucosa

• DOI: 10.1213/01.ane.0000262040.19721.26
• Publication Date: 2007-05-15T08:01:19Z
• Authors: Michelle Franz-Mo...; André L. R. Silva; Karina Cogo; Cristiane de C. B...; Maria C. Volpato; José Ranali; Eneida de Paula; Francisco C. Groppo
• Keywords: Ropivacaine; Benzocaine; Interquartile range; Prilocaine; Topical anesthetic

In Brief BACKGROUND: The elimination of pain caused by needle insertion for local anesthesia would be a significant advance in dentistry. METHODS: this blinded cross-over study we evaluated the efficacy liposome-encapsulated ropivacaine topical anesthesia. Thirty healthy volunteers received 60 mg anesthetics: Liposome-encapsulated 1% ropivacaine, plain 2.5% lidocaine and prilocaine mixture (EMLA), 20% benzocaine gel, buccal fold upper-right canine 2 min different sessions. After 30-G needles, was rated on visual analog scale (VAS). A pinprick test used to measure duration pulpar response assessed an electric pulp tester. RESULTS: VAS median interquartile range (in cm) were 0.8 (0.4–1.5), 1.6 (0.8–2.6), 1.1 (0.3–2.7), 2.2 (0.9–2.9) EMLA, groups, respectively. group showed lower mean values when compared with (P = 0.0205). soft tissue 11 (7–14), 6.5 (4–11), 14 (11–16), 7 (6–9) EMLA just as efficient reducing pain, longer other anesthetics 0.0001). CONCLUSION: Liposomal-encapsulated gel equivalent EMLA® during None effective inducing pulpal IMPLICATIONS: Liposome encapsulation enhanced anesthetic properties which comparable discomfort into oral mucosa.