The Effect of Preoperative Heart Rate and Anxiety on the Propofol Dose Required for Loss of Consciousness

• DOI: 10.1213/ane.0b013e3181c5bd11
• Publication Date: 2009-12-17T13:31:34Z
• Authors: Séverine Gras; Frédérique Servin; Ennoufous Bedairia; Philippe Montravers; Jean-Marie Desmonts; Dan Longrois; Jean Guglielminotti
• Keywords: Adult; Male; Psychiatric Status Rating Scales; Adolescent; Dose-Response Relationship, Drug; Unconsciousness; Anxiety; Middle Aged; Perioperative Care; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Heart Rate; Anesthesia, Intravenous; Humans; Hypnotics and Sedatives; Female; Propofol; Anesthetics, Intravenous; Aged

Conflicting results have been reported on the effect of anxiety propofol dose required for inducing loss consciousness (LOC). The hemodynamic effects anxiety, increased heart rate (HR), and cardiac output may account these discrepancies. We therefore designed this study to address, first, perioperative HR LOC and, second, HR.Forty-five ASA physical status I-II female patients undergoing gynecological surgery were studied. Anxiety was assessed in operating room with State-Trait Inventory (STAI)-state Spielberger scale (situational anxiety). After recording, anesthesia induced a 200-mL/h 1% infusion Base Primea pump (Fresenius-Vial, Brezins, France) until LOC. recorded at time Relationships between STAI-state versus tested Spearman test P value 0.01.A significant relationship observed (rho = 0.487, 0.0012) but not 0.330, 0.0306). However, 0.462 0.0054).Increased is associated Perioperative accounts HR.