Long-term Recordings of Local Field Potentials From Implanted Deep Brain Stimulation Electrodes

• DOI: 10.1227/neu.0b013e3182676b91
• Publication Date: 2012-07-13T16:51:33Z
• Authors: Aviva Abosch; David Lanctin; Ibrahim Onaran; Lynn Eberly; Maggie Spaniol; Nuri Firat Ince
• Keywords: Local field potential; Subthalamic Nucleus; Movement Disorders

BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus is an effective treatment for Parkinson disease. However, DBS not responsive to individual's disease state, and programming parameters, once established, do change reflect state. Local field potentials (LFPs) recorded from electrodes are being investigated as potential biomarkers no patient data exist about what happens LFPs over lifetime implant. OBJECTIVE: We whether LFP amplitude response limb movement differed between patients implanted acutely with 2 7 years previously. METHODS: at surgery time (9 subjects), 3 weeks after initial placement (median: 3.5) later during programmable generator replacement (11 sides). power-frequency spectra each bipolar electrode derivations adjacent contacts were calculated 5-minute resting 30-second epochs. Monopolar impedance used evaluate trends time. RESULTS: There was significant difference in β-band implantation (OR) 3-week post-OR times (P = .94). lower than OR .008) recordings .039). Impedance measurements declined < .001). CONCLUSION: Postoperative activity can be demonstrates a similar profile acute recordings, although may decrease. These results support feasibility constructing closed-loop, patient-responsive device based on activity. ABBREVIATIONS: DBS, deep IPG, LFP, local MAC, monitored anesthesia care mUPDRS, Unified Parkinson's Disease Rating Scale OR, PD, PostOR, (3-4 implant) RMS, root mean square STN,