Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism

• DOI: 10.1242/bio.20149811
• Publication Date: 2014-12-13T03:27:40Z
• Authors: Stephanie M. Coss...; Adam J. Gastonguay; Xiaoping Bao; Alexandra Lerch-G...; Ling Zhong; Leanne M. Harmann; Christopher Koceja; Robert Q. Miao; Padmanabhan Vakeel; Changzoon Chun; Keguo Li; Jamie Foeckler; Michelle Bordas; Hartmut Weiler; Jennifer Strande; Sean P. Palecek; Ramani Ramchandran
• Keywords: Organoid

In this study, we have identified a novel member of the AMPK family, namely Sucrose non-fermenting related kinase (Snrk), that is responsible for maintaining cardiac metabolism in mammals. SNRK expressed heart, and brain, cell types such as endothelial cells, smooth muscle cells cardiomyocytes (CMs). Snrk knockout (KO) mice display enlarged hearts, die at postnatal day 0. Microarray analysis embryonic 17.5 blood profile neonates defect lipid metabolic pathways. knockdown CMs showed altered phospho-acetyl-coA carboxylase phospho-AMPK levels similar to global conditional KO mouse. Finally, adult mouse displays severe functional defects lethality. Our results suggest essential homeostasis, shows an autonomous role during mammalian development.