Hippocampus-like corticoneurogenesis induced by two isoforms of the BTB-zinc finger geneZbtb20in mice

• DOI: 10.1242/dev.000265
• Publication Date: 2007-02-15T01:18:35Z
• Authors: Jakob V. Nielsen; Flemming H. Nielsen; Rola Ismail; Jens Noraberg; Niels A. Jensen
• Keywords: Cerebral Cortex; 0301 basic medicine; Pyramidal Cells; Mice, Transgenic; Zinc Fingers; Hippocampus; Transgenic; Mice; 03 medical and health sciences; Cell Movement; Animals; Protein Isoforms; Transcription Factors

Hippocampus-associated genes that orchestrate the formation of compact stratum pyramidale are largely unknown. The BTB (broad complex, tramtrack,bric-a-brac)-zinc finger gene Zbtb20 (also known as HOF, Znf288,Zfp288) encodes two protein isoforms, designated Zbtb20S and Zbtb20L, which expressed in newborn pyramidal neurons presumptive hippocampus mice. Here, we have generated transgenic mice with ectopic expression Zbtb20L immature differentiated from multipotent non-hippocampal precursors. subiculum posterior retrosplenial areas these were transformed into a three-layered hippocampus-like cortex homogenous cell layer. Severe malformations lamination occur neocortical areas, coincide deficiency cortical markers. alterations cytoarchitecture result behavioral abnormalities suggestive deficient processing visual spatial memory cues cerebral adult Overall,our vivo data suggest functions molecular switch for pathway induces invariant neuron morphogenesis suppression fate transitions neurons.