pannierandpointedP2act sequentially to regulateDrosophilaheart development

• DOI: 10.1242/dev.00488
• Publication Date: 2003-05-20T00:21:48Z
• Authors: Alejandra D. Alvarez; Weiyang Shi; Beth A. Wilson; James B. Skeath
• Keywords: Heart development

The Drosophila heart consists of two major cell types: cardioblasts, which form the contractile tube heart; and pericardial cells, flank cardioblasts are thought to filter detoxify blood or hemolymph fly. We present completion entire lineage all cells. Notably, we detect a previously unappreciated distinction between lineages cells located in posterior seven segments relative those more anteriorly. Using genetic screen, have identified ETS-transcription factor pointed as key regulator cardioblast fates heart. In this domain, promotes development opposes development. find that function is carried out primarily if not exclusively by pointedP2 isoform and, context, may act independently Ras/MAPK pathway activity. go on show GATA transcription pannier acts early dorsal mesoderm promote cardiac thus Finally, demonstrate upstream developmental formation, subsequently domain distinguish fates.