Drosophilaglypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process

• DOI: 10.1242/dev.00958
• Publication Date: 2004-01-16T20:43:01Z
• Authors: Chun Han; Tatyana Y. Belenkaya; Bei Wang; Xinhua Lin
• Keywords: Morphogen; Decapentaplegic

The signalling molecule Hedgehog (Hh) functions as a morphogen to pattern field of cells in animal development. Previous studies Drosophila have demonstrated that Tout-velu (Ttv), heparan sulphate polymerase, is required for Hh movement across receiving cells. However, the molecular mechanism Ttv- mediated poorly defined. We show Dally and Dally-like (Dly), two glypican members proteoglycan (HSPG) family, are substrates Ttv essential movement. embryos lacking dly activity exhibit defects distribution its subsequent signalling. both Dly involved functionally redundant during wing further demonstrate regulated by cell-to-cell independent dynamin-mediated endocytosis. propose glypicans transfer along cell membrane