Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development

• DOI: 10.1242/dev.025767
• Publication Date: 2008-10-24T01:06:52Z
• Authors: Fenglei He; Wei Xiong; Xueyan Yu; Ramon Espinoza-Lewis; Chao Liu; Shuping Gu; Michiru Nishita; Kentaro Suzuki; Gen Yamada; Yasuhiro Minami; YiPing Chen
• Keywords: WNT5A; Secondary palate

Tissue and molecular heterogeneities are present in the developing secondary palate along anteroposterior (AP) axis mice. Here, we show that Wnt5a its receptor Ror2 expressed a graded manner AP of palate. deficiency leads to complete cleft palate, which exhibits distinct phenotypic alterations at histological, cellular levels anterior posterior regions We demonstrate there is directional cell migration within In absence Wnt5a, this does not occur. Genetic studies vitro organ culture assays further role for mediating signaling regulation proliferation during development. Our results reveal regulatory roles gene expression an essential migration.