Persistent competition among stem cells and their daughters in theDrosophilaovary germline niche

• DOI: 10.1242/dev.033340
• Publication Date: 2009-02-12T02:07:19Z
• Authors: Christa Rhiner; Begoña Díaz; Marta Portela; Juan F. Poyatos; Irene Fernández-...; Jesús M. López-Gay; Offer Gerlitz; Eduardo Moreno
• Keywords: Stem cell niche

Cell competition is a short-range cell-cell interaction leading to the proliferation of winner cells at expense losers, although either cell type shows normal growth in homotypic environments. Drosophila Myc (dMyc; Dm-FlyBase) potent inducer wing epithelia, but its role ovary germline stem niche unknown. Here, we show that (GSCs) with relative lower levels dMyc are replaced by GSCs higher dMyc. By contrast, dMyc-overexpressing outcompete wild-type without affecting total numbers. We also provide evidence for naturally occurring border formed high dMyc-expressing and low progeny, which may facilitate concentration niche-provided self-renewal factor BMP/Dpp metabolically active cells. Genetic manipulations impose uniform across produce an extended Dpp signaling domain cause uncoordinated differentiation events. propose dMyc-induced plays dual regulating optimal pools sharp boundaries, potentially harmful case emerging dmyc duplications occupancy pre-cancerous Moreover, competitive interactions among be relevant successful application therapies humans.