The C. elegans tailless/Tlx homolog nhr-67 regulates a stage-specific program of linker cell migration in male gonadogenesis

• DOI: 10.1242/dev.035477
• Publication Date: 2009-11-11T17:48:03Z
• Authors: Mihoko Kato; Paul W. Sternberg
• Keywords: Orphan receptor

Cell migration is a common event during organogenesis, yet little known about how temporally coordinated with organ development. We are investigating stage-specific programs of cell using the linker (LC), migratory crucial for male gonadogenesis C. elegans. During L3 and L4 larval stages wild-type males, LC undergoes changes in its position along route, transcriptional regulation unc-5 netrin receptor zmp-1 zinc matrix metalloprotease, morphology. have identified tailless homolog nhr-67 as cell-autonomous, regulator timing programs. In nhr-67-deficient animals, each stage either severely delayed or never occurs, development before early after mid-L4 occurs normal timing. propose that there basal program utilized throughout modified by regulators such nhr-67.