Slit2 and Robo3 modulate the migration of GnRH-secreting neurons

• DOI: 10.1242/dev.079418
• Publication Date: 2012-08-21T16:49:16Z
• Authors: Anna Cariboni; William D. Andrews; Fani Memi; Athena R. Ypsilanti; Pavol Zelina; Alain Chedotal; John G. Parnavelas
• Keywords: Forebrain; Vomeronasal organ; Roundabout; Slit

Gonadotropin-releasing hormone (GnRH) neurons are born in the nasal placode and migrate along olfactory vomeronasal axons to reach forebrain settle hypothalamus, where they control reproduction. The molecular cues that guide their migration have not been fully identified, but thought either cell movement directly or patterning of axonal substrates. Using genetically altered mouse models we show GnRH is modulated by Slit2 Robo3, members axon guidance Slit ligand Robo receptor families. Mice lacking Robo3 a reduced number forebrain, normal complement supporting axons, pointing direct role for these molecules neuron migration.