FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney

• DOI: 10.1242/dev.089078
• Publication Date: 2013-11-28T03:02:53Z
• Authors: Jennifer L. Fetting; Justin A. Guay; Michele J. Karolak; Renato V. Iozzo; Derek C. Adams; David E. Maridas; Aaron C. Brown; Leif Oxburgh
• Keywords: Progenitor

Forkhead transcription factors are essential for diverse processes in early embryonic development and organogenesis. Foxd1 is required during kidney its inactivation results failure of nephron progenitor cell differentiation. expressed interstitial cells adjacent to cells, suggesting an role the niche nephrogenesis. To better understand how cortical general, FOXD1 particular, influence niche, we examined differentiation states two subtypes Foxd1(-/-) tissue. We found that although retained a primitive CITED1-expressing compartment, prematurely differentiate. identify pathways regulated by FOXD1, screened target genes comparison null wild-type tissues. gene encoding small leucine-rich proteoglycan decorin (DCN) repressed show compound genetic Dcn partially rescues null. demonstrate DCN antagonizes BMP/SMAD signaling, which transition state primed WNT-induced epithelial On basis these studies, propose mechanism retention misexpressed produced differentiated accumulates extracellular matrix, inhibiting BMP7-mediated compartment they can respond induction signals.