The origin of reactive oxygen species in mouse embryos cultured in vitro

• DOI: 10.1242/dev.113.2.551
• Publication Date: 2021-04-26T01:42:39Z
• Authors: M. Mohammad Nasr-...; Martin H. Johnson
• Keywords: Xanthine

ABSTRACT The increase in production of reactive oxygen species such as H2O2 at the G2/M phase second cell cycle may be related to vitro block development mouse 2-cell embryos. occurrence rise is independent activation embryonic genome and passage through S, G2 M phases first G1 cycle, but does require unfertilized oocyte. produced via dismutation superoxide by enzyme dismutase. Production mitochondrial, NADPH-oxidase xanthine/xanthine oxidase systems has been investigated. evidence suggests that superoxide, thereby H2O2, system, an involvement other generating not excluded. relation between discussed.