Lin28 promotes the proliferative capacity of neural progenitor cells in brain development

• DOI: 10.1242/dev.120543
• Publication Date: 2015-04-28T11:20:28Z
• Authors: Mei Yang; Si-Lu Yang; Stephanie Herrlinger; Chen Liang; Monika Dzieciatko...; Kirk C. Hansen; Ridham Desai; Andras Nagy; Lee Niswander; Eric G. Moss; Jian-Fu Chen
• Keywords: LIN28; Neural Development; Ectopic expression; Progenitor

Neural progenitor cells (NPCs) have distinct proliferation capacities at different stages of brain development. Lin28 is an RNA-binding protein with two homologs in mice: Lin28a and Lin28b. Here we show that Lin28a/b are enriched early NPCs their expression declines during neural differentiation. single-knockout mice reduced NPC proliferation, enhanced cell cycle exit a smaller brain, whereas lacking both alleles one Lin28b allele display similar but more severe phenotypes. Ectopic results increased numbers size. Mechanistically, physically functionally interacts Imp1 (Igf2bp1) regulates Igf2-mTOR signaling. The function could be attributed, least part, to the regulation mRNA targets encode Igf1r Hmga2. Thus, overlapping functions temporally regulating