Targeted ablation of glia disrupts axon tract formation in the Drosophila CNS

• DOI: 10.1242/dev.121.11.3703
• Publication Date: 2021-04-26T02:12:46Z
• Authors: Alicia Hidalgo; Joachim Urban; Andrea H. Brand
• Keywords: Growth cone; Neuroglia

ABSTRACT Glial cells are thought to play a role in growth cone guidance, both insects and vertebrates. In the developing central nervous system of Drosophila embryo, interface glia form scaffold prior extension first pioneer cones. Growing axons appear contact glial as axon tracts established. We have used novel technique for targeted cell ablation kill thus test their establishment embryonic tracts. show that early development leads complete loss longitudinal Ablation later results defects comprising weakening fascicles within connectives. conclude required guidance formation embryo then either direct follower cones, or maintain