Notch1 is required for the coordinate segmentation of somites

• DOI: 10.1242/dev.121.5.1533
• Publication Date: 2021-04-26T02:21:37Z
• Authors: Ronald A. Conlon; Andrew G. Reaume; Janet Rossant
• Keywords: Somitogenesis

ABSTRACT Members of the Notch family transmembrane receptors mediate a number developmental decisions in invertebrates. In order to study function vertebrate organism, we have mutated Notch1 gene mouse. is required for embryonic survival second half gestation. first gestation, found no effect mutation on normal programs neurogenesis, myogenesis or apoptosis. We conclude that not essential these processes, at least early postimplantation development. However, somitogenesis delayed and disorganized mutant embryos. propose normally coordinates process somitogenesis, provide model how this might occur.