Coordinate developmental control of the meiotic cell cycle and spermatid differentiation in Drosophila males

• DOI: 10.1242/dev.122.4.1331
• Publication Date: 2021-04-26T02:39:33Z
• Authors: Ting-Yi Lin; Sridhar Viswanathan; Cricket Wood; Patricia G. Wilson; Nurit Wolf; Margaret T. Fuller
• Keywords: Spermatid; Spermatocyte; Spermiogenesis; Meiosis II

ABSTRACT Wild-type function of four Drosophila genes, spermatocyte arrest, cannonball, always early and meiosis I is required both for cell-cycle progression through the G2/M transition in males onset spermatid differentiation. In mutant any one these meiotic arrest mature primary spermatocytes with partially condensed chromosomes accumulate post-meiotic cells are lacking. The occurs prior to degradation cyclin A protein. block spermatogenesis mutants not simply a secondary consequence as differentiation proceeds cell cycle activating phosphatase twine. Instead, spermiogenesis suggests control point that may serve coordinate male program. phenotype strikingly similar histopathological features maturation infertility human males, suggesting be conserved from flies man.