The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

• DOI: 10.1242/dev.122.5.1409
• Publication Date: 2021-04-26T02:35:31Z
• Authors: U. Ahlgren; J. Jonsson; H. Edlund
• Keywords: PDX1; Mesenchyme; Enteroendocrine cell

We have previously shown that mice carrying a null mutation in the homeobox gene ipf1, now renamed to pdx1, selectively lack pancreas. To elucidate level at which PDX1 is required during development of pancreas, we this study analyzed early stages pancreas ontogeny PDX-/- mice. These analyses revealed inductive events leading formation pancreatic buds and appearance insulin glucagon cells occur PDX1-deficient embryos. However, subsequent morphogenesis epithelium progression differentiation endocrine are arrested pdx1-/- In contrast, mesenchyme grows develops, both morphologically functionally, independently epithelium. also show pdx1 mutants unable respond mesenchymal-derived signal(s) normally promote morphogenesis. Together these data provide evidence PDX-1 acts cell autonomously due defect