Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila
Smoothened
Compartment (ship)
engrailed
Compartmentalization (fire protection)
Patched
Lineage (genetic)
DOI:
10.1242/dev.124.20.4053
Publication Date:
2021-04-26T03:00:48Z
AUTHORS (2)
ABSTRACT
ABSTRACT It is thought that the posterior expression of ‘selector’ genes engrailed and invected control subdivision growing wing imaginal disc Drosophila into anterior lineage compartments. At present, cellular mechanisms by which separate compartments are maintained not known. Most models have assumed presence or absence selector gene autonomously drives compartment-specific adhesion recognition molecules inhibit intermixing between However, our present understanding Hedgehog signalling from to cells raises some interesting alternative based on a cell’s response signalling. We show here lack smoothened, thus ability receive signal, no longer obey restriction in normal position anterior-posterior boundary. Rather these clones extend anatomically territory, without any changes engrailed/invected expression. also examined lacking both en inv; too complex behaviors near site compartment boundary, do always cross entirely anatom-ically territory. Our results suggest compart-mentalization process involving intercom-partmental signalling; affinity growth will be discussed.
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