Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis

• DOI: 10.1242/dev.124.22.4627
• Publication Date: 2021-04-26T03:09:50Z
• Authors: Kiyoshi Iida; Haruhiko Koseki; Hideaki Kakinuma; Naoko Kato; Yoko Mizutani-Koseki; Hideyo Ohuchi; Hidefumi Yoshioka; Sumihare Noji; Koichi Kawamura; Yuki Kataoka; Fukuko Ueno; Masaru Taniguchi; Nobuaki Yoshida; Toshihiro Sugiyama; Naoyuki Miura
• Keywords: Mesenchyme

Mesenchyme Fork Head-1 (MFH-1) is a forkhead (also called winged helix) transcription factor defined by common 100-amino acid DNA-binding domain. MFH-1 expressed in non-notochordal mesoderm the prospective trunk region and cephalic neural-crest mesoderm-derived mesenchymal cells prechordal of early embryos. Subsequently, strong expression localized developing cartilaginous tissues, kidney dorsal aortas. To investigate developmental roles during embryogenesis, mice lacking locus were generated targeted mutagenesis. MFH-1-deficient died embryonically perinatally, exhibited interrupted aortic arch skeletal defects neurocranium vertebral column. Interruption seen mutant was same as human congenital anomalies. These results suggest that has indispensable extensive remodeling neural-crest-derived skeletogenesis derived from neural crest mesoderm.