Neural crest induction in Xenopus: evidence for a two-signal model

• DOI: 10.1242/dev.125.13.2403
• Publication Date: 2021-04-26T03:14:44Z
• Authors: Carole LaBonne; Marianne Bronner-...
• Keywords: Neural fold; Crest; Chordin; Cranial neural crest

ABSTRACT We have investigated the molecular interactions underlying neural crest formation in Xenopus. Using chordin overexpression to antagonize endogenous BMP signaling whole embryos and explants, we demonstrate that such inhibition alone is insufficient account for induction vivo. find, however, chordin-induced plate tissue can be induced adopt fates by members of FGF Wnt families, growth factors previously been shown posteriorize tissue. Overexpression a dominant negative XWnt-8 inhibits expression markers, demonstrating necessity signal during The requirement direct, whereas FGF-mediated may mediated signals. zinc finger transcription factor Slug, one earliest markers formation, induction. Slug-expressing ectoderm will generate presence or FGF-like signals, bypassing need this process. A two-step model proposed.