SDF-1α induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells

• DOI: 10.1242/dev.128.11.1971
• Publication Date: 2021-04-26T05:50:48Z
• Authors: Robyn S. Klein; Joshua B. Rubin; Hilary D. Gibson; Elliot N. DeHaan; Xavier Alvarez-He...; Rosalind A. Segal; Andrew D. Luster
• Keywords: Granule cell; Granule (geology); Cytoarchitecture

The chemokine SDF-1α (CXC12) and its receptor CXCR4 have been shown to play a role in the development of normal cerebellar cytoarchitecture. We report here that both induces chemotactic responses granule precursor cells enhances cell proliferative Sonic hedgehog. Chemotactic are greater obtained from cerebella animals first postnatal week, coinciding with observed vivo peak expression. activation neuronal differs leukocytes SDF-1α-induced calcium flux is activity dependent, requiring predepolarization KCl or pretreatment glutamate. However, as case leukocytes, all abolished by pertussis toxin, suggesting they occur through Gαi activation. In conclusion, plays two important processes maturation – proliferation migration assisting achievement appropriate number position cortex.