TheCaenorhabditis eleganspolarity geneooc-5encodes a Torsin-related protein of the AAA ATPase superfamily

• DOI: 10.1242/dev.128.22.4645
• Publication Date: 2021-04-26T04:45:48Z
• Authors: Stephen E. Basham; Lesilee S. Rose
• Keywords: AAA proteins; Polarity (international relations)

The PAR proteins are required for polarity and asymmetric localization of cell fate determinants in C. elegans embryos. In addition, several the conserved localized asymmetrically polarized cells Drosophila, Xenopus mammals. We have previously shown that ooc-5 ooc-3 mutations result defects spindle orientation early particular, these genes affect re-establishment protein asymmetry P1 two-cell now report encodes a putative ATPase Clp/Hsp100 AAA superfamilies proteins, with highest sequence similarity to Torsin proteins; gene human A is mutated individuals early-onset torsion dystonia, neuromuscular disease. Although family roles diverse cellular activities, many involved assembly or disassembly complexes; thus, OOC-5 may function as chaperone. co-localizes marker endoplasmic reticulum all blastomeres embryo, pattern indistinguishable from OOC-3 protein. Furthermore, depends on normal gene. These results suggest secretion cell, implications study dystonia.