BMP signaling is required for development of the ciliary body

• DOI: 10.1242/dev.129.19.4435
• Publication Date: 2021-04-25T14:39:52Z
• Authors: Shulei Zhao; Qin Chen; Fang-Cheng Hung; Paul A. Overbeek
• Keywords: Optic vesicle; Optic cup (embryology); Ciliary muscle

The ciliary body in the eye secretes aqueous humor and glycoproteins of vitreous maintains intraocular pressure. muscle controls shape lens through zonules to focus image onto retina. During embryonic development, epithelium is derived from optic vesicle, but molecular signals that control morphogenesis are unknown. We report lens-specific expression a transgenic protein, Noggin, can block BMP signaling mouse result failure formation processes. Co-expression BMP7 restores normal development epithelium. Ectopic Noggin also promotes differentiation retinal ganglion cells. These results indicate required for may play role regulation neuronal developing eye.