A transcriptional profile of multicellular development inDictyostelium discoideum

• DOI: 10.1242/dev.129.7.1543
• Publication Date: 2021-04-23T22:47:54Z
• Authors: Nancy Van Driessche; Chad Shaw; Mariko Katoh; Takahiro Morio; Richard Sucgang; Miroslava Ibarra; Hidekazu Kuwayama; Tamao Saito; Hideko Urushihara; Mineko Maeda; Ikuo Takeuchi; Hiroshi Ochiai; William Eaton; Jeffrey Tollett; John Halter; Adam Kuspa; Yoshimasa Tanaka; Gad Shaulsky
• Keywords: Multicellular organism; Eukaryote; Slime Mold

A distinct feature of development in the simple eukaryote Dictyostelium discoideum is an aggregative transition from a unicellular to multicellular phase. Using genome-wide transcriptional analysis we show that this accompanied by dramatic change expression more than 25% genes genome. We also transcription patterns these are not sensitive strain or nutritional history, indicating robust physiological process stereotypical events. Analysis two differentiated cell types, spores and stalk cells, their precursors revealed large number differentially expressed as well unexpected gene expression, which shed new light on timing possible mechanisms cell-type divergence. Our findings provide perspectives complexity developmental program fraction genome regulated during development. Supplemental data available on-line