Onset of neuronal differentiation is regulated by paraxial mesoderm and requires attenuation of FGF signalling

• DOI: 10.1242/dev.129.7.1681
• Publication Date: 2021-04-23T22:50:42Z
• Authors: Ruth Diez del Corral; Dorette N. Breitk...; Kate G. Storey
• Keywords: Paraxial mesoderm; Intermediate mesoderm; GDF7; Somitogenesis; FGF8

While many neuronal differentiation genes have been identified, we know little about what determines when and where neurons will form how this process is coordinated with the of neighbouring tissues. In most vertebrates onset takes place in spinal cord a head to tail sequence. Here demonstrate that changing signalling properties adjacent paraxial mesoderm control progression neurogenesis chick cord. We find an inverse relationship between expression caudal neural prospective cord, which maintained by underlying presomitic FGF signalling, differentiation, repressed such signals accelerated somitic mesoderm. show key interaction ability repress Fgf8 transcription Our findings further indicate attenuation prerequisite for may also help resolve mesodermal cell fates. However, inhibition alone does not promote formation neurons, requires still somite signalling. propose model from tissue promotes serves co-ordinate development.