The Drosophila neurogenin Tap functionally interacts with the Wnt-PCP pathway to regulate neuronal extension and guidance

• DOI: 10.1242/dev.134155
• Publication Date: 2016-07-07T00:48:01Z
• Authors: Liqun Yuan; Shu Hu; Zeynep Okray; Xi Ren; Natalie De Geest; Annelies Claeys; Jiekun Yan; Eric Bellefroid; Bassem A. Hassan; Xiao-Jiang Quan
• Keywords: Dishevelled; Mushroom bodies; Neurite

The neurogenin (Ngn) transcription factors control early neurogenesis and neurite outgrowth in mammalian cortex. In contrast to their proneural activity, function growth is poorly understood. Drosophila has a single predicted Ngn homolog, Tap, of unknown function. Here we show that Tap not protein but required for proper axonal guidance neurons the mushroom body, neuropile associative learning memory. Genetic expression analyses suggest inhibits excessive by fine regulation levels Wnt signaling adaptor Dishevelled.