The extracellular metalloprotease AdamTS-A anchors neural lineages in place within and preserves the architecture of the central nervous system

• DOI: 10.1242/dev.145854
• Publication Date: 2017-08-01T00:30:21Z
• Authors: James B. Skeath; Beth A. Wilson; Selena E. Romero; Mark J. Snee; Yi Zhu; Haluk Lacin
• Keywords: ADAMTS; Perlecan

The extracellular matrix (ECM) regulates cell migration and sculpts organ shape. AdamTS proteins are metalloproteases known to modify ECM promote migration, but demonstrated roles for in regulating CNS structure ensuring lineages remain fixed place have not been uncovered. Using forward genetic approaches Drosophila, we find that reduction of AdamTS-A function induces both the mass exodus neural out drastic perturbations structure. Expressed active surface glia, acts parallel perlecan opposition viking/collagen IV βPS-integrin keep rooted preserve structural integrity CNS. tissue stiffness oppose perlecan, which reduces stiffness. Our work supports a model anchors cells preserves architecture by reducing