Tracing the destiny of mesenchymal stem cells from embryo to adult bone marrow and white adipose tissue via Pdgfrα expression

• DOI: 10.1242/dev.155879
• Publication Date: 2018-01-30T01:10:34Z
• Authors: Hiroyuki Miwa; Takumi Era
• Keywords: Fetal Proteins; Homeodomain Proteins; 0301 basic medicine; Receptor, Platelet-Derived Growth Factor alpha; Adipose Tissue, White; SOXB1 Transcription Factors; Gene Expression Regulation, Developmental; Bone Marrow Cells; Cell Differentiation; Mesenchymal Stem Cells; Mice, Mutant Strains; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Pregnancy; Animals; Cell Lineage; Female; T-Box Domain Proteins; Biomarkers

ABSTRACT Mesenchymal stem cells (MSCs) are somatic that can be derived from adult bone marrow (BM) and white adipose tissue (WAT), display multipotency self-renewal capacity. Although MSCs essential for formation have already been used in clinical therapy, the origins markers of these remain unknown. In this study, we first investigated developmental process mouse embryos using gene encoding platelet-derived growth factor receptor α (Pdgfra) as a marker. We then traced expressing Pdgfra other genes (brachyury, Sox1 Pmx1) various mutant until stage. This tracing MSC destinies indicates embryonic emerge waves almost all BM WAT originate mesoderm Pdgfrα-positive cells. Furthermore, demonstrate involved some pathological conditions.