mTOR controls embryonic and adult myogenesis via mTORC1

• DOI: 10.1242/dev.172460
• Publication Date: 2019-03-14T15:35:25Z
• Authors: Nathalie Rion; Perrine Castets; Shuo Lin; Leonie Enderle; Judith R. Reinhard; Christopher Eickh...; Markus A. Rüegg
• Keywords: Sirolimus

ABSTRACT The formation of multi-nucleated muscle fibers from progenitors requires the fine-tuned and coordinated regulation proliferation, differentiation fusion, both during development after injury in adult. Although some key factors that are involved different steps well known, how intracellular signals integrated is largely unknown. Here, we investigated role cell-growth regulator mTOR by eliminating essential components complexes 1 (mTORC1) 2 (mTORC2) mouse progenitors. We show inactivation mTORC1, but not mTORC2, developing causes perinatal death. In adult, mTORC1 deficiency stem cells greatly impinges on injury-induced regeneration. These phenotypes because defects proliferation fusion capacity targeted However, mTORC1-deficient partially retain their myogenic function. Hence, our results mTORC2 an important embryonic adult myogenesis, they point to alternative pathways compensate for loss mTORC1. This article has associated ‘The people behind papers’ interview.