Cyclin B2 is required for progression through meiosis in mouse oocytes

• DOI: 10.1242/dev.172734
• Publication Date: 2019-04-05T13:16:14Z
• Authors: Enrico Maria Dald...; Xuan G. Luong; Cai-Rong Yang; Jonathan Kuhn; Marco Conti
• Keywords: Maturation promoting factor; Cyclin B1; Cyclin B; Cyclin A; Cdc25; Cyclin A2

Cyclins associate with cyclin-dependent serine/threonine kinase 1 (CDK1) to generate the M phase-promoting factor (MPF) activity essential for progression through mitosis and meiosis. Although cyclin B1 (CCNB1) is required embryo development, previous studies concluded that CCNB2 dispensable cell cycle progression. Given findings of high