Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling

• DOI: 10.1242/dev.188276
• Publication Date: 2021-01-18T16:43:48Z
• Authors: Pauline Antonie U...; Yuanbin Xie; Godwin Sokpor; Linh Pham; Orr Shomroni; Tea Berulava; Joachim Rosenbusch; Uttiya Basu; Andre Fischer; Huu Phuc Nguyen; Jochen F. Staiger; Tran Tuoc
• Keywords: Forebrain

Fine-tuned gene expression is crucial for neurodevelopment. The program tightly controlled at different levels, including RNA decay. N6-methyladenosine (m6A) methylation-mediated degradation of essential brain development. However, m6A methylation impacts not only stability, but also other metabolism processes. How decay contributes to development largely unknown. Here, we show that Exosc10, a exonuclease subunit the exosome complex, indispensable forebrain We report cortical cells undergo overt apoptosis, culminating in agenesis upon conditional deletion Exosc10 mouse cortex. Mechanistically, directly binds and degrades transcripts P53 signaling-related genes, such as Aen Bbc3. Overall, our findings suggest role suppressing pathway, which rapid turnover apoptosis effectors Bbc3 mRNAs cell survival normal histogenesis.