Timely Schwann cell division drives peripheral myelination in vivo via the laminin/cAMP pathway

• DOI: 10.1242/dev.200640
• Publication Date: 2022-08-08T09:05:01Z
• Authors: Aya Mikdache; Marie-José Boueid; Emilie Lesport; Brigitte Delespierre; Julien Loisel-Duw...; Cindy Degerny; Marcel Tawk
• Keywords: Schwann cell

Schwann cells (SCs) migrate along peripheral axons and divide intensively to generate the right number of prior axonal ensheathment; however, little is known regarding temporal molecular control their division its impact on myelination. We report that Sil, a spindle pole protein associated with autosomal recessive primary microcephaly, required for mitotic exit SCs. In sil-deficient cassiopeia (csp-/-) mutants, SCs fail radially sort myelinate axons. Elevation cAMP, but not Rac1 activity, in csp-/- restores myelin ensheathment. Most importantly, we show significant decrease laminin expression within posterior lateral line nerve forcing Laminin 2 fully ability myelinate. Thus, demonstrate an essential role timely SC mediating orchestrate radial sorting myelination vivo.