BMP and STRA8 act collaboratively to ensure correct mitotic-to-meiotic transition in the fetal mouse ovary

• DOI: 10.1242/dev.204227
• Publication Date: 2025-01-16T13:10:06Z
• Authors: Fiona K. M. Cheung; Chun-Wei Allen Feng; Clare Crisp; Yuji Mishina; Cassy M. Spiller; Josephine Bowles

A successful mitosis-to-meiosis transition in germ cells is essential for fertility sexually reproducing organisms. In mice and humans, it has been established that expression of STRA8 crucial meiotic onset both sexes. Here, we show BMP signalling also essential, not induction but correct progression female mouse fetal cells. Largely agreement with evidence from primordial cell-like (PGCLCs) vitro, cell-specific deletion receptor 1A (BMPR1A; ALK3) caused aberrant retention pluripotency marker OCT4 was compromised; however, the timely Stra8 unaffected. Comparing transcriptomes Bmpr1a-cKO Stra8-null models, reveal interplay between effects function. Our results verify a role instructing cell meiosis vivo, shed light on regulatory mechanisms underlying development.