Golgi polarization in a strong electric field

• DOI: 10.1242/jcs.01646
• Publication Date: 2005-02-23T04:24:12Z
• Authors: Jin Pu; Min Zhao
• Keywords: Cell polarity

Directional cell migration requires proper polarization. The redistribution of the Golgi apparatus is an important event in polarization and many types cells, as a polarized supplies membrane components for leading edge protrusion. Direct current electric fields induce directional wide variety cells. Here we show that 300 mV/mm robust CHO Asymmetric Src PI 3-kinase signalling well actin polymerization are essential field-induced migration. polarizes at same time cells change morphology migrate directionally response to field. turn significantly reinforces maintains optimal electrotaxis. It not known whether electrical signals, when contradicting other cues, still able polarize direct Most strikingly, simply follow direction applied field ignore all cues generated by wounding monolayer Thus, predominant cue mediated signalling.