Loss of α10β1 integrin expression leads to moderate dysfunction of growth plate chondrocytes
Integrins
0303 health sciences
Bone Development
Genotype
Integrin beta1
Green Fluorescent Proteins
Bone and Bones
Mice
03 medical and health sciences
Chondrocytes
Animals, Newborn
Cell Adhesion
Animals
Immunoprecipitation
Collagen
Growth Plate
Coloring Agents
Integrin alpha Chains
Alleles
Gene Deletion
In Situ Hybridization
Cell Proliferation
DOI:
10.1242/jcs.01678
Publication Date:
2005-02-16T01:29:03Z
AUTHORS (6)
ABSTRACT
Integrin alpha10beta1 is a collagen-binding integrin expressed on chondrocytes. In order to unravel the role of alpha10 during development, we generated mice carrying constitutive deletion gene. The mutant had normal lifespan and were fertile but developed growth retardation long bones. Analysis skeleton revealed defects in plate after birth characterized by disturbed columnar arrangement chondrocytes, abnormal chondrocyte shape reduced proliferation. Electron microscopy plates from newborn an increased number apoptotic chondrocytes density collagen fibrillar network compared these structures control mice. These results demonstrate that plays specific morphogenesis function.
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CITATIONS (116)
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