CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function

• DOI: 10.1242/jcs.063859
• Publication Date: 2010-03-09T20:51:07Z
• Authors: Abdelaziz Beqqali; Jantine Monshouwe...; Rui Monteiro; Maaike Welling; Jeroen Bakkers; Elisabeth Ehler; Arie Verkleij; Christine Mummery; Robert Passier
• Keywords: Myofilament

In recent years, the perception of Z-disc function has changed from a passive anchor for myofilaments that allows transmission force, to dynamic multicomplex structure, capable sensing and transducing extracellular signals. Here, we describe new protein, which named CHAP (cytoskeletal heart-enriched actin-associated protein), expressed in differentiating heart skeletal muscle vitro vivo. Interestingly, addition its sarcomeric localization, was also able translocate nucleus. associated with filamentous actin cytoplasm nucleus when ectopically vitro, but rat neonatal cardiomyocytes, disrupted subcellular localization α-actinin, another protein. More importantly, knockdown zebrafish resulted aberrant cardiac development function. These findings suggest is critical component sarcomere an important role development.