CEACAM1: a key regulator of vascular permeability

• DOI: 10.1242/jcs.073635
• Publication Date: 2010-11-17T02:10:25Z
• Authors: Anne-Laure Nouvion; Malika Oubaha; Sarah LeBlanc; Elaine C. Davis; Holger Jastrow; Robert Kammerer; Valérie Breton; Claire Turbide; Suleyman Ergun; Jean-Philippe Gra...; Nicole Beauchemin
• Keywords: Vascular permeability

Carcinoembryonic antigen cell adhesion molecule-1 (CEACAM1) is an immunoglobulin-like surface co-receptor expressed on epithelial, hematopoietic and endothelial cells. CEACAM1 functions as molecule, mainly binding to itself or other members of the CEA family. We others have previously shown that crucial for in vivo vascular integrity during ischemic neo-vascularization. Here, we deciphered roles normal pathological vascularization. found Ceacam1−/− mice exhibit a significant increase basal permeability related increased Akt nitric oxide synthase (eNOS) activation primary murine lung cells (MLECs). Moreover, deletion MLECs inhibits VEGF-mediated (NO) production, consistent with defective VEGF-dependent mice. In addition, Ceacam1-null tumor vasculature. Finally, demonstrate tyrosine-phosphorylated upon VEGF treatment SHP-1- Src-dependent manner, key residues long cytoplasmic domain are phosphorylation NO production. This data represents first report, our knowledge, functional link between VEGFR2/Akt/eNOS-mediated pathway.