The Aurora kinase Ipl1 is necessary for spindle pole body cohesion during budding yeast meiosis

• DOI: 10.1242/jcs.086652
• Publication Date: 2011-08-30T16:48:29Z
• Authors: Katelan Shirk; Hui Jin; Thomas H. Giddings; Mark Winey; Hong-Guo Yu
• Keywords: Spindle pole body; Meiosis II; Microtubule organizing center; Aurora B kinase

In budding yeast, the microtubule-organizing center is called spindle pole body (SPB) and shares structural components with centriole, central core of animal centrosome. During meiotic interphase I, SPB duplicated when DNA replication takes place. Duplicated SPBs are linked then separate to form a bipolar required for homolog separation in meiosis I. II, again, absence replication, four that establish two spindles sister-chromatid II. Here, we report Aurora kinase Ipl1, which necessary cohesion, also maintenance tight association between during meiosis, term cohesion. Premature loss cohesion leads overduplication formation multipolar spindles. By contrast, Polo-like Cdc5 duplication interacts antagonistically Ipl1 at ensure proper separation. Our data suggest coordinates dynamics chromosome segregation cycles yeast meiosis.