TIG3 Interaction at the Centrosome Alters Microtubule Distribution and Centrosome Function

• DOI: 10.1242/jcs.096495
• Publication Date: 2012-03-17T03:34:23Z
• Authors: Tiffany M. Scharadin; Haibing Jiang; Stuart Martin; Richard L. Eckert
• Keywords: Microtubule nucleation; Centrosome cycle; Microtubule organizing center

TIG3 is an importantpro-differentiation regulator that expressed in the suprabasal epidermis. We have shown activates select keratinocyte differentiation-associated processesleading to cornified envelop formation. However, also suppresses cell proliferation by unknown mechanism. Our present studies suggest growth cessation may be mediated via impact of on centrosome and microtubules. The regulates microtubule function interphase cells spindle formation mitotic cells. show co-localizes with γ-tubulin pericentrin at centrosome. localization alters nucleation reduces anterograde growth, increases acetylation detyrosination α-tubulin, insoluble tubulin drives a peripheral ring adjacent plasma membrane. In addition, separation, but not duplication, proliferation. propose regulate observed keratinocytes differentiated epidermis play role these