Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability

• DOI: 10.1242/jcs.115.12.2559
• Publication Date: 2021-04-25T17:37:17Z
• Authors: Teresa Odorisio; Cataldo Schietroma; M. Letizia Zaccaria; Francesca Cianfarani; Cecilia Tiveron; Laura Tatangelo; Cristina M. Failla; Giovanna Zambruno
• Keywords: Vascular permeability

Placenta growth factor (PlGF) is a member of the vascular endothelial (VEGF) family, comprising at least five cytokines specifically involved in regulation and/or lymphatic endothelium differentiation. Several lines evidence indicate role for PlGF monocyte chemotaxis and potentiating activity VEGF, but exact function this cytokine not fully understood. To define biological vivo, we have produced transgenic mouse model overexpressing skin by using keratin 14 promoter cassette. Our data that has strong angiogenic properties both fetal adult life. overexpression results substantial increase number,branching size dermal blood vessels as well enhanced permeability. Indeed, intradermally injected recombinant was able to induce vessel permeability wild-type mice. The analysis receptor 1/flt-1 2/flk-1 indicates two receptors are induced mice suggesting mediating effect overexpressed PlGF.