An electron-microscope study of the reaction of collagen with some monoaldehydes and bifunctional aldehydes
Tail
0301 basic medicine
Aldehydes
0303 health sciences
Hot Temperature
Chemical Phenomena
Staining and Labeling
Lysine
Acetaldehyde
Glyoxal
Phosphotungstic Acid
Arginine
Rats
3. Good health
Tendons
Chemistry
Microscopy, Electron
03 medical and health sciences
Solubility
Glutaral
Benzaldehydes
Formaldehyde
Animals
Collagen
DOI:
10.1242/jcs.12.3.933
Publication Date:
2021-04-24T03:14:36Z
AUTHORS (3)
ABSTRACT
ABSTRACT
Rat tail tendon collagen has been treated with the monoaldehydes, formaldehyde, acetaldehyde, propionaldehyde, butyraldehyde and benzaldehyde, and with the dialdehydes, glyoxal and glutaraldehyde. The treated collagen was then examined in the electron microscope using a negative stain. Alterations to the native collagen pattern were seen with formaldehyde, acetaldehyde, propionaldehyde, glyoxal and glutaraldehyde. A correlation was noted between the changes in the band pattern and the degree of cross-linking estimated from chemical and physical changes in the treated collagen and from measurements of cross-linking made by other workers. The results indicate that the use of electron microscopy and negative staining may be a valuable method of assessing the degree of cross-linking in collagen treated with aldehydes and other reagents.
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