Neuroblast niche position is controlled by Phosphoinositide 3-kinase-dependent DE-Cadherin adhesion

• DOI: 10.1242/jcs.203067
• Publication Date: 2017-05-11T13:57:36Z
• Authors: Susan E. Doyle; Matthew C. Pahl; Karsten H. Siller; Lindsay Ardiff; Sarah E. Siegrist
• Keywords: Position (finance)

Correct positioning of stem cells within their niche is essential for tissue morphogenesis and homeostasis. How acquire maintain position remains largely unknown. Here, we show that a subset brain neuroblasts (NBs) in Drosophila utilize Phosphoinositide 3-kinase (PI3-kinase) DE-cadherin to build adhesive contact NB positioning. NBs remain native microenvironment when levels PI3-kinase activity are elevated NBs. This occurs through PI3-kinase-dependent regulation DE-Cadherin-mediated cell adhesion between neighboring cortex glia, ganglion mother daughters. When and/or DE-Cadherin reduced NBs, lose relocate non-native region rich neurosecretory neurons, including those secrete some the insulin-like peptides. Linking strength attachment could provide cancer hematopoietic with means cycle from trophic-poor trophic-rich microenvironments.