β1 integrin is a sensor of blood flow direction
Mice, Knockout
0301 basic medicine
0303 health sciences
Integrin beta1
Cell Line
Mice
03 medical and health sciences
Regional Blood Flow
Stress, Physiological
Human Umbilical Vein Endothelial Cells
Animals
Humans
Female
Mechanoreceptors
Aorta
Research Article
DOI:
10.1242/jcs.229542
Publication Date:
2019-05-10T14:35:23Z
AUTHORS (18)
ABSTRACT
ABSTRACT Endothelial cell (EC) sensing of fluid shear stress direction is a critical determinant vascular health and disease. Unidirectional flow induces EC alignment homeostasis, whereas bidirectional has pathophysiological effects. ECs express several mechanoreceptors that respond to flow, but the mechanism for poorly understood. We determined, by using in vitro systems magnetic tweezers, β1 integrin key sensor force because it activated unidirectional, not bidirectional, shearing forces. activation unidirectional was amplified were pre-sheared same direction, indicating activity feedforward interaction, which hallmark system stability. En face staining EC-specific genetic deletion studies murine aorta revealed essential at sites flow. In summary, decoding blood mechanics promote homeostasis. This article an associated First Person interview with first author paper.
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