Advances on the roles of tenascin-C in cancer

• DOI: 10.1242/jcs.260244
• Publication Date: 2022-09-14T13:53:40Z
• Authors: Alev Yilmaz; Thomas Loustau; Nathalie Salomé; Suchithra Poilil ...; Chengbei Li; Richard P. Tucker; Valerio Izzi; Rijuta Lamba; Manuel Koch; Gertraud Orend
• Keywords: Tenascin C; Tenascin

ABSTRACT The roles of the extracellular matrix molecule tenascin-C (TNC) in health and disease have been extensively reviewed since its discovery over 40 years ago. Here, we will describe recent insights into TNC tumorigenesis, angiogenesis, immunity metastasis. In addition to high levels expression tumors, during chronic inflammation, bacterial viral infection, is also expressed lymphoid organs. This supports potential for control. Advances using murine models with engineered were instrumental important functions as a danger-associated molecular pattern (DAMP) tissue repair revealed multiple actions tumor progression. acts through distinct mechanisms on many different cell types immune cells coming focus targets cancer. We how this knowledge could be exploited cancer management, particular (checkpoint) therapies.