Actin-based protrusions at a glance

• DOI: 10.1242/jcs.261156
• Publication Date: 2023-11-21T09:54:01Z
• Authors: Sevan Belian; Olga Korenkova; Chiara Zurzolo
• Keywords: Filopodia; Nanotubes; Pseudopodia; Cell Communication; Tunneling nanotubes; [SDV.BC] Life Sciences [q-bio]/Cellular Biology; Actins; Cytonemes

ABSTRACT Actin-based protrusions are at the base of many fundamental cellular processes, such as cell adhesion, migration and intercellular communication. In recent decades, the discovery of new types of actin-based protrusions with unique functions has enriched our comprehension of cellular processes. However, as the repertoire of protrusions continues to expand, the rationale behind the classification of newly identified and previously known structures becomes unclear. Although current nomenclature allows good categorization of protrusions based on their functions, it struggles to distinguish them when it comes to structure, composition or formation mechanisms. In this Cell Science at a Glance article, we discuss the different types of actin-based protrusions, focusing on filopodia, cytonemes and tunneling nanotubes, to help better distinguish and categorize them based on their structural and functional differences and similarities.