Matrix metalloproteinases at a glance

• DOI: 10.1242/jcs.261898
• Publication Date: 2024-01-18T14:19:14Z
• Authors: Sven Hey; Stefan Linder
• Keywords: 0301 basic medicine; Extracellular Vesicles; 03 medical and health sciences; Endopeptidases; Membrane Proteins; Matrix Metalloproteinases; Extracellular Matrix

ABSTRACT Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that belong to the group of endopeptidases or matrixins. They are able to cleave a plethora of substrates, including components of the extracellular matrix and cell-surface-associated proteins, as well as intracellular targets. Accordingly, MMPs play key roles in a variety of physiological and pathological processes, such as tissue homeostasis and cancer cell invasion. MMP activity is exquisitely regulated at several levels, including pro-domain removal, association with inhibitors, intracellular trafficking and transport via extracellular vesicles. Moreover, the regulation of MMP activity is currently being rediscovered for the development of respective therapies for the treatment of cancer, as well as infectious, inflammatory and neurological diseases. In this Cell Science at a Glance article and the accompanying poster, we present an overview of the current knowledge regarding the regulation of MMP activity, the intra- and extra-cellular trafficking pathways of these enzymes and their diverse groups of target proteins, as well as their impact on health and disease.