Stretch Activation of a K+ Channel in Molluscan Heart Cells

• DOI: 10.1242/jeb.127.1.191
• Publication Date: 2021-04-25T02:21:43Z
• Authors: Wade J. Sigurdson; Catherine E. Morris; Borys L. Brezden; David R. Gardner
• Keywords: Lymnaea stagnalis

ABSTRACT Heart ventricle cells of Lymnaea stagnalis contain a stretch-activated K+ channel which exhibits two open states and three closed states. Over the range 0 to –25 mmHg (1 = 133·3 Pa), probability that is steeply non-linear function negative pressure. Pressure-dependent decreases in mean times longest component closed-time distribution are observed same (because other show no consistent or sufficiently large changes with pressure) assumed account for increases being open. Channel activity characteristically occurs as bursts time 3·6ms. These contain, on average, 1·7 closings; 78% burst spent state. It concluded stretch-sensitive kinetic an interburst