The Synthesis of 2′-Deoxyadenosine via Stereospecific Coupling Reaction

• DOI: 10.1246/cl.1989.235
• Publication Date: 2006-05-02T07:06:56Z
• Authors: Hiroshi Kawakami; Hajime Matsushita; Yoshitake Naoi; Kazuo Itoh; Hajime Yoshikoshi
• Keywords: Sodium methoxide; Stereospecificity; Deoxyadenosine; Derivative (finance); Deoxyribose; Coupling reaction; Sodium hydroxide

Abstract The coupling reaction of the sodium salt adenine, which could be easily prepared by deprotonation with hydroxide or methoxide, 1-α-chloro-2-deoxyribose derivative proceeded in a good stereospecific manner acetone as solvent to give β-anomer corresponding acylated adenosine.